The Emerging and Pandemic Infections Consortium (EPIC) is a partnership between the University of Toronto and five hospital research partners — The Hospital for Sick Children (SickKids) Research Institute, Lunenfeld-Tanenbaum Research Institute at Sinai Health, Sunnybrook Research Institute, Unity Health Toronto and the University Health Network. Building on our momentum in combating pathogens including SARS-CoV-2, EPIC brings together researchers from different disciplines to facilitate an integrated and innovative response to high-risk, high-burden infectious diseases. EPIC is Canada’s leading initiative for transformative infectious diseases research, linking academic researchers with industry and government partners, training the next generation of research leaders and advocating for science-based policies. Together, we will help prevent future pandemics and advance national and global health for decades to come.